Today, we’re diving into the combined power of high-dose NAD+ and GHK-Cu.
I’m genuinely excited about the technology behind a product called the Push Patch. It uses iontophoresis— which is a completely non-invasive technology that uses gentle electrical currents to push these ingredients deep into the skin and directly into circulation.
But really, this episode isn’t about the product itself—it’s about what’s inside it and how it’s delivered.
*Why NAD+ & GHK-Cu Are Such a Powerful Combo?
First up let’s talk about NAD+. We’ve covered NAD+ in a previous episode, but if you’re new here—or just need a quick refresher—let’s break it down.
NAD+ (Nicotinamide Adenine Dinucleotide) is a co-enzyme that your cells need to produce energy. Think of it like the battery charger for your phone. Your phone has plenty of apps and features, but it can’t do anything without the power. NAD+ is what charges your cells so they can perform their function. Low NAD+ would mean “low battery mode” for your cells.
So as we get older, our NAD+ levels naturally decline. And when that happens, you might notice feeling more tired than usual, slower recovery after workouts, or just a general sense of low energy. When we boost our NAD+ levels, we can actually reverse some of these effects. We’re talking more energy, better metabolism and focus, faster recovery, improved endurance, and some anti-aging benefits.
So how does it actually work? NAD+ plays a huge role in energy production by powering your mitochondria—the tiny energy factories inside your cells. It cycles between two forms, NAD+ and NADH, helping produce ATP, which is basically the energy currency of your body. But NAD+ doesn’t stop at just energy. It also activates sirtuins, the enzymes tied to DNA repair and longevity.
NAD+ also influences cell signaling pathways that help regulate inflammation and your circadian rhythm, so it can help you sleep better and feel more balanced. It even helps insulin sensitivity—which could even play a role in weight management. And, supports neurotransmitters like dopamine and serotonin which lead to clearer thinking, mood support, and better focus. Some studies even suggest NAD+ therapy could help with managing cravings or withdrawal symptoms, particularly for alcohol or opioids, which is pretty remarkable.
Now let’s talk about GHK-Cu. This is a tiny copper peptide that is naturally produced in the human body that has profound regenerative and anti-aging properties.
So, how does it work? First off, it stimulates fibroblast activity, which boosts collagen and elastin production. Translation? Healthier, more resilient skin and faster tissue repair. It can even promote hair growth by activating dermal papilla cells, which are key for healthier, fuller hair.
It also improves mitochondrial efficiency and reduces oxidative stress, which supports better endurance, strength, and faster recovery.
It’s helpful for your brain too, supporting nerve regeneration and helping with cognitive function. And if inflammation is a concern, GHK-Cu helps calm it down systemically (throughout the body).
High-dose NAD+ and GHK-Cu
Let’s dive into what happens when you combine high-dose NAD+ with GHK-Cu and deliver it through iontophoresis, like with the Push Patch.
Starting with energy, NAD+ boosts mitochondrial efficiency, which translates into higher energy levels, less fatigue, and improved physical endurance. GHK-Cu complements this by supporting ATP production, reducing oxidative damage, and enhancing the body’s ability to repair cells.
When it comes to sleep, NAD+ plays a key role in regulating your internal clock, promoting deeper, more restorative rest and helping to reduce symptoms of insomnia, chronic fatigue, and disrupted circadian rhythms.
For skin, hair, and anti-aging, GHK-Cu is a powerhouse. It stimulates collagen production, improves skin elasticity, promotes wound healing, and enhances overall skin tone. It also supports hair follicle regeneration, which can lead to thicker, healthier hair over time.
On the topic of longevity and disease prevention, NAD+ activates sirtuins and DNA repair enzymes, helping to lower oxidative stress and inflammation—two major contributors to chronic disease. GHK-Cu supports immune function and tissue repair, further reducing the risk of age-related health issues.
Athletic performance and recovery also benefit. NAD+ improves muscle endurance and speeds recovery, while GHK-Cu reduces post-exercise inflammation, prevents muscle breakdown, and enhances oxygen utilization and circulation, boosting overall stamina.
Cognitive function is another area where this combination shines. NAD+ replenishes neurotransmitters, improving focus, clarity, and mental sharpness, while also protecting against cognitive decline. GHK-Cu supports neuronal growth and repair, enhancing learning, memory, and overall cognitive resilience.
Finally, for those recovering from traumatic brain injury, NAD+ helps reduce oxidative stress and neuroinflammation and strengthens the blood-brain barrier, limiting ongoing neural damage. GHK-Cu stimulates neurogenesis and synaptic repair, aiding in recovery of both cognitive and motor function, while helping to alleviate brain fog, fatigue, and neurovascular inflammation associated with TBI.
So why am I excited enough to actually talk about this product on the podcast?
Well, beyond the fact that my husband has been using this product for several months and consistently reports more energy, less brain fog, and an overall sense of feeling better and more focused, I recently listened to an interview with Nick Andrews, the co-founder of Push Patch. Here’s a short clip from that conversation (Starts at 43:50):
How Does It Work?
The patch employs iontophoresis, a non-invasive, pain-free method that uses electrical currents to transdermally deliver medication through your skin and directly into the bloodstream.
This technology bypasses the digestive system, allowing more of the active ingredients to reach your cells. It also provides a sustained release, so the benefits last longer than with oral supplements—or even some IV treatments—without the need for frequent, costly injections or infusions.
Thanks again for listening to The Peptide Podcast.
If you’re a clinician listening, and you want guidance on how to integrate this into your practice—or if you’re wondering which patients are likely to benefit the most—you’re always welcome to reach out in the comments.
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Until next time, be well, and have a happy, healthy week.
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